Category Archives: Immune Reactivity & Skin Inflammation

Treatment Saddle Sore

A saddle sore (boil) occurs as a result of moisture, pressure and friction on the buttock area where cyclist sits on the bike seat (saddle). However, this type of sore can also occur anywhere on the buttock. The key concept is skin damage and bacteria entering the damaged skin area.

A saddle sore, much like a boil often begins as a tender, pinkish-red, swollen area that quickly develops to a pea like pimple on the buttock. As it develops it becomes itchy often with a feeling of heat. The discomfort, pain gets worse as it fills with pus/used cells. The discomfort lessens when the saddle sore/boil drains. The sore may drain on its own or it may need to be opened to drain. The saddle sore takes days (a week) to heal and after healing can leave a bruised skin mark at the site of occurrence. It is important to note, this site is vulnerable to recurrence.

Saddle sores are thought to develop due to friction and chafing of the skin over the buttocks, genital region and inner thigh. Essentially, the chafing, and damage of the skin allows bacteria (S. aureus) to penetrate through the epidermis skin layer. The body wants to contain and remove of the bacteria. The body isolates the bacterial resulting in redness and inflammation which is seen and felt as a saddle sore (boil).

āSport Pro™ for saddle sore prevention and treatment.

āSport Pro™ for saddle sore prevention and treatment.

āSport Pro™  is a medicinal skin treatment to protect the skin’s barrier function, reduce chafing in the genital area, and reduce dermal bacterial colonization. āSport Pro™ is formulated to reduce recurrence of saddle sore, to reduce saddle sore symptoms and facilitate skin repair.  CLICK HERE  to learn more about āSport Pro™ skin protectant.

In medicine, a prodrome is an early symptom that often indicates the start of a disease before specific symptoms occur. A saddle sore often has a prodrome affect, catching these early symptoms with  āSport Pro™  medicinal treatment helps to diminish the capacity of saddle sore.


Injury Prevention
Tips to prevent development of skin issues in cyclists include wearing proper bike shorts that help keep the area dry, and reducing repetitive forces and friction between the skin and saddle surface. Shaving the area should be avoided as this irritates the hair follicles and can introduce skin bacteria into the follicles. Various synthetic pads within bike shorts, called chamois, can help reduce injury. Athletes should properly wash shorts between rides. Lubricants such as chamois cream (carried by most biking stores) or petroleum jelly products can also be used to help reduce friction. It is important to adequately clean the skin using soap and water after rides. A “bike fit” should be performed with focus on changing the type of saddle, adjusting the seat height and tilt, and proper handlebar position to help with reducing pressure in areas of concern. Sometimes seats with cutouts or modified noses can help.

Return to Play
Returning to cycling with saddle sores is dependent on symptoms. If the athlete has an active bacterial skin infection, especially if it is making him/her feel poorly, the physician may limit his/her cycling. Tips for returning without worsening sores are to shorten rides, allow a day between rides, use moisture barriers and/or chamois creams as needed, ensure use of clean, breathable biking shorts, use of a seat with good fit, and washing with a good antibacterial soap after rides. If sores worsen despite riding, the athlete may need to cross train off the bike for a few weeks.

Keira and āSport Pro™ are distributed exclusively by Katha-Soma Consumer Health USA.

Katha Tibet Kathá Soma skin therapeutics are for people with vulnerable and troubled skin. Our naturally derived, nutrient enriched skin care formulas penetrate the deepest (epidermis) skin layers to protect and renew skin.

DISCLAIMER The content presented within the Kathá Soma website is not intended as or should be construed as medical advice. Please consult with a healthcare practitioner for individual medical recommendations. Kathá Soma Consumer Health USA/2017


Immune Reactivity and Skin Inflammation

The Kátha-Soma Health Blog provides dialogue to help people living with cancer, chronic disease or slow cell renewal due to aging, minimize their signs & symptoms, achieve daily comfort and maintain quality of life. This health blog was originated January 2013.

The Immune Reactivity & Skin Inflammation category of this health blog provides information about Psoriasis, Eczema, Rosacea, Fibromyalgia, Lupus, Dermatomyositis, Neurodermatitis, HIV/Aids.  Type in a specific health condition in the space bar to the right for more information.

Care & Comfort

Care & Comfort

What Is An Autoimmune Disorder ?
An autoimmune disorder is a condition that occurs when the immune system mistakenly attacks and destroys healthy body tissue. There are more than 80 different types of autoimmune disorders.

Normally the immune system’s white blood cells help protect the body from harmful substances, called antigens. Examples of antigens include bacteria, viruses, toxins, cancer cells, and blood or tissues from another person or species. The immune system produces antibodies that destroy these harmful substances.

In people with an autoimmune disorder, the immune system can not tell the difference between healthy body tissue and antigens. The result is an immune response that destroys normal body tissues. This response is a hypersensitivity reaction similar to the response in allergic conditions.

In allergies, the immune system reacts to an outside substance that it normally would ignore. With autoimmune disorders, the immune system reacts to normal body tissues that it would normally ignore.

A person may have more than one autoimmune disorder at the same time. Examples of autoimmune (or autoimmune-related) disorders include:
• Addison’s disease
• Celiac disease – sprue (gluten-sensitive enteropathy)
• Dermatomyositis
• Multiple sclerosis
• Pernicious anemia
• Psoriasis
• Reactive arthritis
• Rheumatoid arthritis
• Sjogren syndrome
• Systemic lupus erythematosus
• Type I diabetes

Topical corticosteroid medication (applied to the skin) are often first line treatment for the management of autoimmune – inflammatory skin disorders.

However, topical corticosteroids are not used long term because of adverse side effects such as irritation, dryness, skin atrophy (thinning), striae (stretch marks), telangiectasia, folliculitis, acne, purpura (bruising), and allergic contact dermatitis. Additionally, topical corticosteroids can inhibit the skin’s ability to fight against bacterial or fungal infections.

Yet, patients with autoimmune – inflammatory skin disorders often experience recurrence which contributes to dependency on steroid creams.

Maállo is a novel post steroid therapeutic skin cream for use after corticosteroid medication. As a daily maintenance therapeutic Maállo supports the structure and function of the skin to reduce dependency on topical corticosteroids. To learn more about Maállo Cream click here.

DISCLAIMER: Kátha Soma does not provide medical advice, diagnosis or treatment. The information provided is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.

Lupus Skin Rash

Lupus is a chronic inflammatory disease that can affect various parts of the body, especially the skin, joints, blood, and kidneys.

Approximately two-thirds of people with lupus will develop some type of skin disease. Skin disease in lupus can cause rashes or sores (lesions), most of which will appear on sun exposed areas, such as the face, ears, neck, arms, and legs. In addition, 40 to 70 percent of people with systemic lupus will find that their disease is made worse by exposure to ultraviolet rays from sunlight or artificial light. Lupus skin rashes and lesions are often treated by a dermatologist; a physician who specializes in skin conditions.

The Forms of Cutaneous Lupus
Lupus skin disease, called cutaneous lupus erythematosus can occur in one of three forms:

● Chronic cutaneous (discoid) lupus erythematosus

● Subacute cutaneous lupus erythematosus

● Acute cutaneous lupus erythematosus

Chronic Cutaneous Lupus (discoid lupus) appears as disk-shaped, round lesions. The sores usually appear on the scalp and face, but sometimes they will occur on other parts of the body as well. Approximately 10 percent of people with discoid lupus later develop systemic lupus. Discoid Lupus lesions are often red, scaly, and thick. Usually they do not hurt or itch. Over time these lesions can produce scarring and skin discoloration (darkly colored and/or lightly colored areas). Discoid lupus lesions tend be very photosensitive, so preventive measures are important.

Subacute Cutaneous lesions may appear as areas of red scaly skin with distinct edges, or as red, ring-shaped lesions. The lesions occur most commonly on the sun-exposed areas of the arms, shoulders, neck, and body. The lesions usually do not itch or scar, but they can become discolored. Subacute cutaneous lesions are also photosensitive so preventive measures should be taken when spending time outdoors or under fluorescent lights.

Acute Cutaneous Lupus lesions occur when systemic lupus is active. The most typical form of acute cutaneous lupus is a malar rash — flattened areas of red skin on the face that resemble a sunburn. When the rash appears on both cheeks and across the bridge of the nose in the shape of a butterfly, it is known as the “butterfly rash.” However, the rash can also appear on the arms, legs, and body. These lesions tend to be very photosensitive. They typically do not produce scarring, although changes in skin color may occur.

Sourced from: Lupus Foundation of America


Maállo Skin Cream supports the structure & function of each skins layer and is formulated to decrease inflammatory stimulus and resulting skin damage. As a post therapeutic (after the skin condition is stabilized) Maállo supports skin health to reduce the incident and intensity of lupus dermatologic flair-ups. For more information about Maállo Skin Cream click here.


Corticosteroid Cream Skin Damage


Note: the enclosed information is a bit heavy on medical language, however this information does provide a scientific based overview of how corticosteroids – steroid creams over time can weaken the structure of the skin which impedes healing and leaves skin vulnerable to subsequent damage.

Corticosteroid mediated skin breakdown (atrophy) involves thinning of the epidermis (top), dermis (middle) and the hypo-dermis (fatty bottom) skin layers, resulting in increased water permeability and increased transepidermal water loss. The thinning is caused by a decreased proliferative rate of keratinocytes and dermal fibroblasts. The origin of the decreased proliferation lies in collagen turnover. Transforming growth factor β (TGF-β) is a signaling molecule that, among other actions, promotes production of collagen, using Smad proteins as second messengers. Activated GR negatively regulates Smad3 through a protein-protein interaction, in this way, blocking expression of the COL1A2 gene, which encodes a type I collagen chain.

Type I collagen represents roughly 80% of the total share of skin collagen. Therefore, glucocorticoids reduce collagen turnover through blocking of TGF-β actions. Coincidentally, TGF-β plays a central role in the epithelial-to-mesenchymal transition (EMT), an essential mechanism for cicatrisation (scar formation).  Glucocorticoids also diminish synthesis of epidermal lipids.

Furthermore, glucocorticoids reduce collagenases, which are part of the matrix metalloproteinases (MMPs) and tissue inhibitors of the metalloproteinases TIMP-1 and TIMP-2. Striae (stretch marks) formation, which occurs in hypercortisolism and may occur after long-term topical treatment with glucocorticoids, may be explained by the skin tensile strength determined by type I and type III collagens. The thinning of epidermis caused by glucocorticoids’ long-term topical treatment appears also to be related with the repression of K5–K14 keratin genes, which are markers of the basal keratinocytes. Additionally, these drugs inhibit K6–K16 keratin genes, markers of activated keratinocytes, therefore promoting impaired wound healing.

Above Info Source From: Int J Endocrinol. 2012: 561018.
Mechanisms of Action of Topical Corticosteroids in Psoriasis
Luís Uva, Diana Miguel

Essentially, the ongoing use of topical steroid (skin creams) can generate additional skin damage such as epidermal atrophy, degeneration of the dermal structure and collagen deterioration. Additionally, topically applied corticosteroids can inhibit the skin’s ability to fight against bacterial and fungal infections.

Maállo™ . . . naturally.

Maállo is a non-steroid medicinal therapeutic skin ointment that helps to suppress the stimulus of inflammatory skin conditions and supports the natural structure and function of the skin. To learn more about Maállo Ointment click here.

Kátha Soma therapeutics are formulated to help people living with cancer, chronic disease or slow cell renewal due to aging, minimize their sign & symptoms, achieve daily comfort and maintain quality of life.

DISCLAIMER: Kátha Soma does not provide medical advice, diagnosis or treatment. The information provided is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition. www.


Lupus . . . More Complex Skin Conditions

Other conditions that can occur with lupus include:

Calcinosis is caused by a buildup of calcium deposits under the skin. These deposits can be painful, and may leak a white liquid. Calcinosis can develop from a reaction to steroid injections or as a result of kidney failure.

Cutaneous Vasculitis Lesions occur when inflammation damages the blood vessels in the skin. The lesions typically appear as small, red-purple spots and bumps on the lower legs; occasionally, larger knots (nodules) and ulcers can develop. Vasculitis lesions can also appear in the form of raised sores or as small red or purple lines or spots in the fingernail folds or on the tips of the fingers. In some cases cutaneous vasculitis can result in significant damage to skin tissue. Areas of dead skin can appear as sores or small black spots at the ends of the fingers or around the fingernails and toes, causing gangrene (death of soft tissues due to loss of blood supply).

Hair Loss can occur for other reasons besides scarring on the scalp. Severe systemic lupus may cause a temporary pattern of hair loss that is then replaced by new hair growth. A severe lupus flare can result in fragile hair that breaks easily. Such broken hairs at the edge of the scalp give a characteristic ragged appearance termed “lupus hair.”

Raynaud’s phenomenon is a condition in which the blood vessels in the hands and feet go into spasm, causing restricted blood flow. Lupus related Raynaud’s usually results from inflammation of nerves or blood vessels and most often happens in cold temperatures, causing the tips of the fingers or toes to turn red, white, or blue. Pain, numbness, or tingling may also occur.

Livedo Reticularis and Palmar Erythema are caused by abnormal rates of blood flow through the capillaries and small arteries. Signs (what you see) include a bluish, lace like mottling under the skin, especially on the legs giving a “fishnet” appearance. Like Raynaud’s  livedo reticularis and palmar erythema tend to be worse in cold weather.

Mucosal Ulcerations are sores in the mouth or nose or, less often, in lining of vaginal tissue. These ulcers can be caused by both cutaneous lupus and systemic lupus. It is important to differentiate lupus ulcers from herpes lesions or cold sores, which may be brought on by the use of immunosuppressive drugs.

Petechiae (pah-TEE-kee-eye) are tiny red spots on the skin, especially on the lower legs, that result from low numbers of platelet in your blood, a condition called thrombocytopenia.

Sourced from: Lupus Foundation of America

Signs and Symptoms of Lupus

Lupus symptoms depend on what body organs are affected and how seriously they are affected.

People with lupus (systemic lupus erythematosus, or SLE), may be extremely tired, have skin rashes, or have joint pain. If the disease is more complex the kidneys, heart, lungs, blood, or nervous system can be effected.

Signs are what you see . . . Symptoms are what you feel   Lupus

Signs and Symptoms of Lupus include:

Fatigue . . . nearly all people with lupus have mild to extreme fatigue. Even mild cases of lupus cause an inability to engage in daily activities and exercise. Increased fatigue is  often a sign that a symptom flare is about to occur.

 Joint and Muscle Pain . . . most people with lupus have joint pain (arthritis) at some time. About 70% of people with lupus report that joint and muscle pain was their first sign of the disease. Joints may be red and warm, and may swell. Morning stiffness may also be felt. Lupus arthritis often occurs on both sides of the body at the same time, particularly in the wrists, small joints of the hands, elbows, knees, and ankles.

Skin Conditions . . . most people with lupus develop skin rashes. These rashes are often an important clue to the diagnosis. In addition to the butterfly rash over the cheeks and bridge of the nose, other common skin symptoms include skin sores or flaky red spots on the arms, hands, face, neck, or back; mouth or lip sores; and a scaly, red or purple raised rash on the face, neck, scalp, ears, arms, and chest.


Maállo Skin Cream . . . the skin is composed of three layers: the epidermis, dermis and hypodermis. The dermis is the middle layer of the skin; the dermis supports the skins blood and nerve supply.

Maállo Skin Cream supports the structure & function of each skin layer and is formulated to decrease inflammatory stimulus and resulting skin damage. As a post therapeutic (after the skin condition is stabilized) Maállo supports skin health to reduce the incident and intensity of lupus dermatologic flair-ups. To learn more about Maállo Skin Cream click here.

While there is no cure for lupus, early diagnosis and treatment can help in managing the symptoms and lessening the chance of permanent damage to organs or tissues. Because lupus is different for every person, treatments and medications are prescribed based on individual needs.

Treatments for Lupus

The medication used to treat lupus-related skin conditions depends on what kind of cutaneous lupus you have. The most common treatments are ointments, such as steroid cream or gel. In some cases liquid steroids will be injected directly into the lesions.

A new class of drugs, called topical immuno-modulators, has been developed to treat serious skin conditions without the side effects found in corticosteroids: both tacrolimus ointment (Protopic®) and pimecrolimus cream (Elidel®) have been shown to suppress the activity of the immune system in the skin, including the butterfly rash, subacute cutaneous lupus, and possibly even discoid lupus lesions.

In addition, thalidomide (Thalomid®) has been increasingly accepted as a treatment for the types of lupus that affect the skin; it has been shown to greatly improve cutaneous lupus that has not responded to other treatments.

Treatments for Cutaneous Lupus

● Preventative Treatments
Avoidance/protection from sunlight and artificial ultraviolet light
Seek shade
Sunscreens — physical and chemical

● Local/Topical Treatments
Corticosteroid creams, ointments, gels, solutions, lotions, sprays, foams
Calcineurin inhibitors
tacrolimus ointment (Protopic®)
pimecrolimus cream (Elidel®)

● Systemic Treatments for Mild to Moderate Disease
Corticosteroids – short term
hydroxychloroquine (Plaquenil®)
chloroquine (Aralen®)
quinacrine (available from compounding pharmacies only)

Retinoids: synthetic forms of vitamin A—isotretinoin (Accutane®), acitretin (Soriatane®)

Sulfones: diaminodiphenylsulfone (Dapsone®)

● Systemic Treatments for Severe Disease
Corticosteroids – long term
oral—auronofin (Ridura®)
intramuscular— sodium thiomaleate (Myochrisine®)
Thalidomide (Thalomid®)
Azathioprine (Imuran®)
Mycophenolate mofetil (CellCept®)

● Biologics: efalizumab (Raptiva®)

It should be noted that most of the above treatments are not FDA-approved for cutaneous lupus.
Above Information Sourced From: Lupus Foundation of America

Maállo Skin Cream supports the structure & function of the skin layers and has been formulated to decrease inflammatory stimulus and resulting skin damage. As a post therapeutic (after the skin condition is stabilized) Maállo supports skin health to reduce the incident and intensity of lupus dermatologic flair-ups. To learn more about Maállo Skin Cream click here.