Tag Archives: Psoriasis

Psoriasis and T-Cells

Skin has an outer layer called the epidermis and a middle layer called the dermis. Skin cells are created in the dermis and move up through the epidermis to the skin surface. Skin cells are continually dying and being replaced. Normally, skin cells mature and shed in less than a month.

In psoriasis, however, the normal cycle of replacing old skin cells with new ones becomes unbalanced. Skin cells reproduce many times faster than normal and live only three to four days. The dead cells build up on the skin, forming thick, flaky patches called plaques. The redness in skin plaques is caused by increased blood supply to the rapidly multiplying skin cells.

Evidence from research studies suggest that psoriasis is a disorder of the immune system. Normally, the immune system defends the body from infection by bacteria, viruses, and other invaders. Sometimes, however, the immune system makes a mistake and attacks the cells, tissues, and organs of a person’s own body. When this happens, the resulting disease is called an autoimmune disease. Many autoimmune diseases run in families.

The theory that psoriasis is an autoimmune disease is based on the fact that scientists have found abnormally large numbers of t cells (a type of white blood cell) in the red, flaky skin patches of people with psoriasis. T cells are the infantry of the immune system. When the body senses a need to defend itself against infection, it first makes and then releases millions of t cells to fight off the invaders. Some t cells are normally found in skin. The presence of abnormally large numbers of t cells in skin affected by psoriasis suggests that the immune system is attacking the skin by mistake.

Sourced From: EhealthMD.com

Psoriasis A Chronic Autoimmune Disease

Psoriasis is a chronic, autoimmune disease that appears on the skin. It occurs when the immune system sends out faulty signals that speed up the growth cycle of skin cells.
 
There are five types of psoriasis. The most common form, plaque psoriasis, appears as raised, red patches covered with a silvery white buildup of dead skin cells.

Psoriasis can occur on any part of the body
Psoriasis is not contagious.
Psoriasis is the most common autoimmune disease in the U.S. As many as 7.5 million Americans have psoriasis.

Health Conditions Associated with Psoriasis
Individuals with psoriasis are at an elevated risk to develop other chronic and serious health conditions also known as “comorbid diseases” or “comorbidities.” These include heart disease, inflammatory bowel disease and diabetes. People with more severe cases of psoriasis have an increased incidence of psoriatic arthritis, cardiovascular disease, hypertension, diabetes, cancer, depression, obesity, and other immune-related conditions such as Crohn’s disease.

 

Sourced in part from: National Psoriasis Foundation/USA

What is Psoriatic Arthritis

Psoriatic arthritis is a condition in which a person has both psoriasis and a related form of arthritis. Psoriasis is a common skin condition. A person with psoriasis typically has patches of raised red skin with scales. The affected skin can look different depending on the type of psoriasis the individual has. Arthritis is joint inflammation. Psoriatic arthritis is a particular type of aggressive and potentially destructive, inflammatory arthritis.
 
Psoriatic arthritis is an autoimmune disease, meaning that your cells and antibodies (part of your immune system) attack your own tissues. Rarely, a person can have psoriatic arthritis without having obvious psoriasis. Usually, the more severe the skin symptoms are, the greater the likelihood a person will have psoriatic arthritis.
 

Sourced From: 2013 WebMD, Inc.